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Title :複合低エネルギー生体組織接合のコラーゲン構造変化可視化と冠動脈血管吻合への適用
Title alternative :Visualization of structure change of the living tissues with the Integrated Low-level Energies (ILE) adhesion method and development of a coronary artery bypass assist device by using the method
Authors :増澤, 徹
Authors alternative :MASUZAWA, TORU
Issue Date :27-Jun-2018
Abstract :研究成果の概要(和文):低レベル量の100 ℃程度の熱,数10 kPa~1 MPa程度の圧力を生体組織基材であるコラーゲンに与えることにより生体組織の接合を行う新しい生体組織接合方法について研究を行った.コラーゲン変性,再凝固のメカニズムが解明できれば,従来では手縫いの縫合しか手段のなかった血管吻合や止血手技において,人工物に依らない簡便かつ低侵襲,無毒な全く新しい血管吻合技術を確立できる.本研究では,熱によるコラーゲンの形態学的変化の観察とFIB(収束イオンビーム)やSEM(走査型電子顕微鏡)を用いて接合部位構造の可視化を行い,本接合方法の現象を明らかにし,本技術を応用した冠動脈吻合装置を開発し有効性を評価した. 研究成果の概要(英文):The Integrated Low-level Energies (ILE) adhesion method, which is a novel tissue adhesion technique, has been studied. We investigated the effect of thermal energy on the collagen structure in living tissues using ILE adhesion method. The structural changes of the living tissues with the ILE adhesion method were observed by using SEM and FIB microscopes. The dense layer was observed at the adhesion boundary and heat and pressure are significant to create the dense boundary. A coronary artery bypass assist device by using the ILE adhesion method has been developed and evaluated. Bypass grafts were anastomosed on the porcine coronary artery successfully with an adhesion temperature of 120 degrees Centigrade and an adhesion time of 60 seconds. The average anastomosed strength is 18.7 kPa and sufficient adhesion performance is confirmed.
Type Local :科研等報告書
Publisher :茨城大学
URI :http://hdl.handle.net/10109/13999
Appears in Collections:Grants-in-aid for scientific research Report (College of Engineering)

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